The Thai script is used to write the Thai language and other languages, such as Kuy and Pali. The Thai alphabet is is a member of the Indic family of scripts descended from Brahmi. Tradition holds that the script was created in 1283 by King Ramkhamhaeng.

The Tibetan script is used to write the Tibetan language in various countries throughout the Himalayas, including Tibet, Nepal, and northern India, where large Tibetan populations reside. It is also used in Bhutan to write Dzongkha. Tibetan also serves as the language of Buddhist traditions that spread from Tibet into the cultural area of Mongolia. The script and its grammar were reported to be devised in 6C CE by Thonmi Sambhota, who was sent to India to study its languages at the behest of Songstem Gampo, the king of Tibet, as a means to bring Buddhism to Tibet. As a result of its origin, the script has been used to represent Indic words.

The Tifinagh script is used to write various languages commonly called Berber or Amazigh, which are spoken by people living in the Maghreb of North Africa and a few countries of West Africa (Mali, Burkina Faso, and Niger). The script comes from an older form of the alphabet called Libyan. The Tifinagh block in the Unicode Standard is based on the Neo-Tifinagh writing systems which were developed to cover the Maghreb Berber dialects. The characters are based on four Tifinagh character subsets: a basic set from the Institut Royal de la Culture Amazighe (IRCAM), an extended IRCAM set, additional Tifinagh letters, and modern Tuareg letters. Since September 2003, it has been taught in primary schools in Morocco.

The Transport and Map Symbols block comprises a set of symbols limited to transportation and map symbols. Approximately half of the symbols in Unicode 6.0 derive from the emoji sets that are used by Japanese cell phone carriers.

The Ugaritic script is an historical writing system that was used to write the Ugaritic language and other languages, including Hurrian. It is one of the cuneiform scripts and was used from around 1400 BCE until 12C BCE. It was discovered in Ugarit (modern Ras Shamra), Syria, in 1928.

The Unified Canadian Aboriginal Syllabics (UCAS) block represents a unification of various local syllabaries of Canada, based on the shapes of the characters. James Evans invented the syllabics in the late 1830s for the Algonquian languages. The script is used by several aboriginal communities throughout Canada, including speakers of the Algonquian, Inuktitut, and Athapascan language families. Today UCAS is also used by governmental agencies and in business, education, and media.

The Vai script is used for the Vai language, spoken in Liberia and Sierra Leone. It was devised by Dualu Bukele (Momolu Duwalu Bukele) of Liberia ca. 1830, and has been in use since then. Standardization efforts took place in 1899 and 1962. Vai speakers today also use the Arabic and Latin scripts.

The Vedic Extensions set includes symbols that are used in Vedic texts. They appear in the four core texts of the Vedas (Samaveda, Yajurveda, Rigveda, and Atharvaveda) and in the prose text on Vedic ritual (Satapathabrahmana). The characters in this block may be used with Devanagari, as well as other Indic scripts. Though the language of the Rig Veda, the oldest of the Vedas, may date to as early as 1500 BCE, most extant written texts date to much later. The block also includes a set of characters used to indicate tone.

The Vertical Forms block is made up of vertical punctuation compatibility characters that were needed to map to the Chinese standard GB 18030. For text laid out vertically, regular punctuation marks are used instead, with alternate glyphs provided by the font.

The traditional Yi script, known as Cuan or Wei, is an ideographic script used to write the Yi language, dating perhaps to the Tang Dynasty (618-907 CE). This script does not seem to derive from Han ideographs. The earliest known inscription is dated to 1485. Until modern times, the script was used primarily to write religious, medical, and geneological texts that were passed down by priests in individual villages, and hence was not used as a general means of communication between communities. To promote literacy in Yi, a standardized version of the traditional script that was used to write the Liangshan dialect of the Yi language (spoken in southern western China) was officially put forward.in 1980. The ideographic characters were transformed into a syllabary in this script and these appear in the Yi blocks in Unicode. However, the Yi block characters are not suitable for writing other dialects, only the Liangshan dialect. A different system using Latin letters, called "black Yi writing", was also devised for Yi in the 1950s and has been used by Yi Christians.

The Yijing Hexagram Symbols is a block of Chinese symbols that first appeared in the text called Zhou Yi ("the Zhou Dynasty classic of change"), which may have originated about 1000 BCE. Today the book is known as the Yijing, I Ching, or Book of Changes. There are 64 hexagrams and they are still used today in many print and electronic publications.