The Sharada script is an important historical Brahmi-based script used for Kashmiri, Sanskrit and a number of other languages of northern South Asia. The Sharada script was the main inscriptional and literary script of Kashmir from 8C to 20C, and is still in use in rituals and to write horoscopes by a small group of Kashmiri Pandits. The historical spread of the script ranges from northern India, Pakistan, and Afghanistan.

The Shavian script, also known as the Shaw script, is used for the phonetic spelling of English and contains 40 letters. Playwright George Bernard Shaw directed in his will that the Public Trustee in Britain search for and publish an alphabet for English with 40 (or fewer) letters. This request from Shaw was an attempt to address the idiosyncrasies of English orthography. The script that was selected was devised by Kingsley Read, but has not met with widespread acceptance. A version of Shaw's play Androcles and the Lion: An Old Fable Renovated was published containing English spelling and Shavian, and is generally accepted as the normative version of the script.

The Sinhala script, also called Sinhalese, is used to write the Sinhala language (the majority language in Sri Lanka), Tamil, and the liturgical languages Pali and Sanskrit. The script descends from Brahmi and resembles the scripts of South Asia.

Small form variants is a block of small variants of ASCII punctuation marks, including a small ampersand, small percent sign, small question mark and a small comma. These were encoded in the Unicode Standard as compatibility characters from the Chinese standard, CNS 11643.

The Sora Sompeng script is used to write the Sora language in the Orissa-Andhra border area of India. The script was developed in 1936 by Mangei Gomango, based on a vision of 24 letters that he received. The script is used today in religious contexts and appears in a variety of published materials.

The Spacing Modifier Letters block is primarily made up of a set of phonetic modifiers used to indicate that the pronunciation of an adjacent letter is different in some way, or to mark stress or tone. In some cases, the character may itself represent a sound. The block includes many characters required for the International Phonetic Alphabet, and a number of Uralic Phonetic Alphabet modifers. Spacing clones of diacritics, specified in some corporate standards, are also included.

The Sundanese script is used to write the Sundanese language, which is spoken on west Java in Indonesia.  Sundanese is a descendant of the Brahmi script, and hence is related to many other scripts of South Asia and Southeast Asia that are derived from Brahmi. Today Sundanese is primarily written using the Latin script, but the Sundanese script is taught in the schools and appears on signage. Old Sundanese (Sunda Kuna) dates from 14C to 18C, and is handled by the characters in the Sundanese and the Sundanese Supplement blocks. Modern Sundanese has been in use from the 17C. The current form of the script was made official in 1996.

The Superscripts and Subscripts block includes letters or digits that are positioned above or below the baseline in typographical layout. In many cases, superscripts and subscripts should be handled with style or mark-up (instead of using the characters from this block), in cases where the raised or lowered characters do not belong to plain text. The exception is when the superscript or subscript letters are part of a specialized phonetic alphabet, such as the Uralic Phonetic Alphabet. Several of the characters in this block derive from other standards or vendor code pages, and are considered compatibility characters.

The Syloti Nagri script is used for writing the Sylheti language, an Indo-European language spoken in the Barak Valley region of northeast Bangladesh and southeast Assam in India. The script is derived from Brahmi. It has traditionally been dated to 14C, but may be dated to 16C or 18C.

The Syriac script is used for writing a number of modern languages and dialects, including literary usages, Neo-Aramaic dialects, Garshuni (Arabic written in the Syriac script), Christian Palestinian Aramaic, and historically for writing Armenian, Persian, and other languages. The earliest datable Syriac writing dates from the 6 CE. Syriac is also the active liturgical language for several communities in the Middle East (Syrian Orthodox, Assyrian, Maronite, Syrian Catholic, and Chaldaean) and southeast India (Syro-Malabar and Syro- Malankara).

The Tagalog script was used to write Tagalog, Bisaya, Ilocano, and other languages in the Philippines. There are accounts dated to the mid-1500s written by Spanish missionaries mentioning the Tagalog script. However, the script fell out of common usage by the mid-1700s. The modern Tagalog language, also known as Filipino, is today written in the Latin script. The Tagalog script is a Brahmi-derived script, distantly related to the South Indian scripts. It is closely related to the Buhid, Hanunóo, and Tagbanwa scripts of the Philippines, though it may not be their direct parent. The ancestor of all four Philippine scripts may have been transported to the Philippines via palaeographic scripts of western Java between the 10 and 14 C CE.

Tagbanwa is a living script used to write the Tagbanwa language (also known as Apurahuanoin) in Palawan, the Philippines. Tagbanwa is a Brahmi-derived script, distantly related to the South Indian scripts. It is closely related to the Hanunóo and Buhid scripts of the Philippines. All three scripts are related to Tagalog, but may not be directly descended from it. The ancestor of these Philippine scripts (including Tagalog) may have been transported to the Philippines via palaeographic scripts of western Java between the 10 and 14 C CE.

The Tai Le script is used to write the Tai Le language (also known as Tai Nüa, Dehong Dai, Tai Mau, Tai Kong, and Chinese Shan), spoken primarily in south central Yunnan, China. The script derives from Old Dehong Dai, whose history goes back some 700-800 years. The present form of the script dates to ca. 1954, when a systematic representation of the tones was introduced with the use of combining diacritics. The script was revised again in 1988.

Tai Tham script, sometimes called Lanna, Old Tai Lue, or Old Xishuangbanna Dai, is a descendant of the Brahmi and Old Mon script. It is used for the Kam Mu'ang (Northern Thai), Tai Lue, and Khün languages. It is also used for religious purposes to write Lao Tham (Old Lao), and can be found as the alphabet of old manuscripts in temples in Northern Thailand.

The Tai Viet script is used to write three Tai languages spoken primarily in northwestern Vietnam, northern Laos, and central Thailand—Tai Dam (also known as Black Tai or Tai Noir), Tai Dón (White Tai or Tai Blanc), and Thai Song (Lao Song or Lao Song Dam). The script reflects great diversity in the traditional form of the script, depending upon the community. There has been an attempt to establish a standard for the Tai script, which was called Unified Alphabet. The script is used today by the Tai people in Vietnam.

The Tai Xuan Jing symbols include sets of monogram, digram and tetragram signs. These symbols appeared in China in a text called Tai Xuan Jing (literally, “the exceedingly arcane classic”), composed in 2 BCE by Yang Xiong (53 BCE-18 CE). The text is known in the West by several titles, including The Alternative I Ching and The Elemental Changes. The work is still published today.

The Takri script is used to write a variety of languages in the western regions of the Himalayas, present day Jammu and Kashmir, Himachal Pradesh, Panjab, and Uttarakand. It was used primarily during 17C to 20C. Takri is derived from the Sharada family of Brahmi scripts. There are reports of revival efforts of Takri to write languages as Dogri, Kishtwari, and Kulvi. A number of regional varieties of the script exist.

The Tamil script descends from the South Indian branch of Brahmi. It is used to write the Tamil language of the Tamil Nadu state in south India and surrounding states, as well as for minority languages such as Badaga, Irula, Paniya, and Saurashtra. Tamil is also spoken in Sri Lanka, Singapore, and parts of Malaysia.

The Telugu script is used to write the Telugu language, spoken in the south central Indian state of Andhra Pradesh and nearby states. It is also used to write minority languages such as Gondi and Lambadi. It became a distinct script in 13C CE. Telugu is has a common descendent with the Kannada script.

The Thaana (or Taana, Tāna) script is used to write the modern Dhivehi (Divehi) language of the Republic of Maldives. Although Thaana has borrowed many of its glyphs from Arabic and shares a number of features with Arabic writing, Thaana is a true alphabet because the writing of vowels is mandatory. Thaana also derives some of its letters from an earlier script that was used on the Maldives, Dhives Akuru. Thaana was developed in the 18C and largely replaced Dhives Akuru at that time.